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Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key pathophysiological event in human ChAc cells, we took advantage of Vps13a-/- mice, which phenocopied human ChAc. Using proteomic approach, we found accumulation of active Lyn, γ-synuclein and phospho-tau proteins in Vps13a-/- basal ganglia secondary to impaired autophagy leading to neuroinflammation

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egetable intake were associated with increased risk of future incident hospital admissions with multimorbidity. Age, male **** and potentially modifiable lifestyle behaviours including smoking, body mass index, physical inactivity and low fruit and vegetable intake were associated with increased risk of future incident hospital admissions with multimorbidity. Tinea capitis is the most common form of dermatophytosis among children, contributing significantly to the global burden of skin and hair infections. However, an accurate account of its burden in Africa

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ClinicalTrials.gov Identifier NCT01701635.Doubts surrounding the potential adverse effects of antimicrobial preservatives have modified the demand of consumers, who increasingly insist on the production of low-level and even preservative-free cosmetics. Protection of the product against microbial contamination is therefore focused on the packaging. This has prompted the emergence of a highly diverse array of so-called "protective", "overprotective", and "barrier" packaging. However, these designations are not normalized and the choice o

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0.70 to 1.13), but at 2 years post-diagnosis, the nosocomial group was associated with 137 % higher costs (CR 2.37, 95 % CI 1.51 to 3.7.Conclusion. In multivariable analysis, nosocomial infections were associated with significantly higher long-term costs up to 2 years post-infection. Hydrocephalus, intracranial epidural abscess and cerebral oedema were the most common complications, and lumbar punctures and ventricular catheter placement were the most common neurosurgical procedures. This study represents the first nation-wide, longitu

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The Integrated Oven: A Comprehensive Guide In modern kitchen areas, the trend toward incorporating appliances with cabinets to create a seamless look has actually acquired substantial traction. Among these necessary kitchen tools, the integrated oven stands apart as a favored alternative for many property owners and cooking enthusiasts. This article explores the advantages, features, and considerations connected with integrated ovens, as well as answering typically asked concerns. What is an Integrated Oven? A

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After the training, the number of remote consultations increased from 2 to 12 in primary care, 12 to 35 in homecare and decreased from 28 to 17 in the hospital setting. We conclude that training nurses in telehealth activities contributes to their knowledge and self-efficacy.As the airways of SARS-CoV-2 infected patients contain a high viral load, bronchoscopy is associated with increased risk of patient to health care worker transmission due to aerosolised viral particles and contamination of surfaces during bronchoscopy. Bronchosco

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Buying a German Driving License Legally: A Comprehensive Guide Acquiring a driving license is a considerable milestone for individuals, particularly in countries like Germany where public transport is not always readily offered. For who want to drive in Germany, acquiring a German driving license is vital. However, the process of obtaining a driving license can be complex and lengthy, leading some to look for alternative paths. In this article, we will explore the legal ways to buy a German driving l