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SLC30A8 encodes the zinc transporter ZnT8. SLC30A8 haploinsufficiency protects against type 2 diabetes (T2D), suggesting that ZnT8 inhibitors may prevent T2D. We show here that, while adult chow fed Slc30a8 haploinsufficient and knockout (KO) mice have normal glucose tolerance, they are protected against diet-induced obesity (DIO), resulting in improved glucose tolerance. We hypothesize that this protection against DIO may represent one mechanism whereby SLC30A8 haploinsufficiency protects against T2D in humans and that, while SLC30A8 i

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The trend presented a different behavior depending on the level of development of the region studied. The main causes of near miss were preeclampsia (47%), hemorrhage (24%), and sepsis (18%).  The objective of the present study was to analyze the reasons that led to hormone therapies (HTs) regimen changes in women with breast cancer.  This was a retrospective cross-sectional study from a single-institution Brazilian cancer center with patient records diagnosed with breast cancer between January 2012 and January 2017.  From

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5 g/kg IBW 30 days after discharge home. Weight loss after 30 days at home remained at -1.8 ± 2.7 kg. Colorectal surgery, even in an ERP, is associated with energy and protein intake below the targets recommended for the rehabilitation phase and results in weight loss. Whether nutrition counseling and prolonged administration of protein-enriched oral supplements could accelerate weight gain needs to be explored. Colorectal surgery, even in an ERP, is associated with energy and protein intake below the targets recommended for the

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71 to 2.16 nm were all ultra-small (more than half were nanoclusters less then 2 nm) and highly dispersed, owing to the high electrostatic attraction of the negatively charged hydroxyls and the anchoring effect of the micropores on the hydroxylated surface of the Janus SiNSs. Therefore, the Ag/xSn-SiNSs nanocomposites displayed better catalytic properties for 4-nitrophenol reduction than most Ag-based supported catalysts, and the optimal Ag/2.4Sn-SiNSs catalyst exhibited quick reaction within 80 s and turnover frequency (TOF) of 3.3

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They also showed reduction in mortality which was statistically significant in less severe cases with mild or moderate ARDS. Early administration of the convalescent plasma could successfully contribute to the treatment of severe COVID-19 patients with mild or moderate ARDS at risk of progressing to critical state. Antero-posterior trans pelvic diameter (APD) and renal scintigraphy play a significant role in the diagnosis of pelvi-ureteric junction (PUJ) obstruction and postoperative follow-up following pyeloplasty. However, the APD vari

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An amendment to this paper has been published and can be accessed via the original article.In a recent issue of this Journal, Politzer, Shmueli, and Avni estimate the economic costs of health disparities due to socioeconomic status (SES) in Israel (Politzer et al., Isr J Health Policy Res 8 46, 2019). Using three measures of SES, the socioeconomic ranking of localities, individual income, and individual education, Politzer and colleagues estimate welfare loss due to higher mortality, productivity loss due to poorer health, excess hea

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CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipenser dabryanus, the gene expression patterns of CRF system have been investigated after different energy status. CRF and two receptors have been studied in Acipenser dabryanus in previous study, thus, four components of CRF system (UI, UCN2, UCN3

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We report a new approach for infrared spectroscopic analysis of fiberglass materials using a mirror substrate, which allowed the specular reflection from the sample surface to be minimized and detect the light passing through the sample. The application of this technique for platinum-containing fiberglass catalysts made it possible for the first time to identify sulfate compounds formed in glass fibers during the oxidation reaction of sulfur dioxide. The developed technique can be applied for a number of research samples that are

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Although abscopal tumor regression remains a rare phenomenon, interest in exploiting how radiation stimulates the immune system to induce systemic abscopal response is increasing. Here, we tested the hypothesis that tumor immunogenicity determined the ability of radiotherapy to induce abscopal effects. We established highly (MC-38 and E.G7-OVA) or poorly (LL/2 and B16-F1 immunogenic tumor models in this study and treated them with sham radiation, a single dose of 15 Gy, or three fractions of 5 Gy on three consecutive days. Alteration