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5 vs 20 hours ± 4.8, P= .06) in patients requiring multiple follow-up visits (12.2 ± 5 vs 7.6 ± 3.9, P .001). Multiple regression analyses identified heart rate 100 beats/min and systolic PAP 55 mm Hg as associated with the need for extended CDT. Extended CDT did not result in a higher hemorrhagic complication rate (1/45 vs 6/111, P= .7). Patients presenting with higher heart rates and systolic PAP may benefit from extended CDT to achieve similar reductions in PAP and thrombus burden, without clear added risk of hemorrhag