https://www.selleckchem.com/pe....ptide/octreotide-ace
This study shows that chronic intrathecal M3G sensitises animals to mechanical stimulation and elevates substance P levels in the nociceptive laminae of the spinal cord. Chronic M3G also induces antinociceptive cross-tolerance to morphine. Thus, chronic M3G exposure might contribute to morphine-induced tolerance and opioid-induced hyperalgesia. With the advent of novel high throughput techniques, an extensive number of non-coding RNAs have been recognized to be involved in the pathogenesis of different types of hematological m
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