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d size of AAA. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Recently, the review "Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome" by Holm Nielsen et al. came out in the Journal of Internal Medicine. Here, authors provided a wide and exhaustive overview of the central role played by extracellular matrix (ECM) proteins in determining plaque instability. These aspects are of utmost importance as we believe they represent th