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The muscles, vastus medialis, vastus lateralis, and extensor digitorum longus, displayed a lower level of force production when interacting with the minimalist shoe design. Runners who wear negative running shoes may find themselves transitioning to a midfoot strike. Increased muscular exertion in the gastrocnemius lateralis, Achilles tendon, and flexor hallucis longus muscles might portend a greater likelihood of Achilles tendinopathy and ankle flexor injuries. The use of negative runnin