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2% of patients after 6 months of treatment (P less then 0.0001). The mean MMS increased from 68.8 to 83.1 (P less then 0.0001). A decrease in steroid dosage ( less then 10 mg/day) was effective in 57.9% of treated patients. In all, 42.8% of patients experienced adverse events infections (21.4% of patients); infusion reaction (7%); bradycardia (3.7%); and cytopenia (7%). Conclusion The present study demonstrates the efficacy and safety of rituximab in patients with MG. Additional studies remain necessary to determine the role of rituximab in the pharmacopeia