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The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic a****ual and ****ual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validation of naphthylisoquinoline (NIQ) alkaloids and their synthetic analogues as multistage active antimalarial drug candidates. A total of 30 compounds were tested, of which 17 exhibited IC50 values 7% after 30 min. Dioncophylline C (2a) emerged as a front runner from the study, displaying activity
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