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Nicotine 0.5mg/kg and CSE 0.5mg/kg significantly induced reward effects (p0.05). There was no decrease of reward effect during the extinction-reinstatement stage of the postconditioning phase (p0.05), while quercetin 50mg/kg both induced along with nicotine or CSE was able to inhibit the reward effect of nicotine (p0.05). Quercetin reduced the risk of nicotine dependence and has a potential effect to use as a therapy for nicotine dependence, especially as a preventive agent. Quercetin reduced the risk of nicotine dependence a