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A spatially resolved, multimodal, single-cell approach was employed to expose a detailed picture of the immune micromilieu within pancreatic ductal adenocarcinoma (PDAC). Our investigation of the immune compartment in treatment-naive PDAC tumors, matched normal pancreatic tissue, and the systemic circulation relied on single-cell RNA sequencing, spatial transcriptomics, multiplex immunohistochemistry, and mass cytometry. In a meta-analysis, we examined prognostic as