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After DCI, the aRR for clinical improvement in the HTI group on day one was 163 (95% confidence interval 117-227). A subsequent measurement on day five indicated a reduced aRR of 104 (95% confidence interval 84-129). The secondary outcomes were indistinguishable when comparing the two groups. The analyses of the treated group and the per-protocol group produced comparable outcomes. Following DCI, no beneficial effects of HTI are