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Expression of mRNA was negatively regulated by its DNA methylation (r=-0.398, P0.0001). Moreover, silencing of in HepG2 cell line inhibited the proliferation and migration and led to cell cycle arrest at G0/G1 stage by reducing cyclinD1, CDK2, CDK4, and CDK6 expression, while overexpression of PIGC in Hcclm3 cell line revealed the opposite effect. is related to aggressive clinical features, and overexpression of signifies worse survival in patients with HCC. promotes proliferation and migration of cancerous liver cells through the r
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