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05). The number of peripheral blood monocytes in UC+Cit group was significantly lower than that in UC group (p less then 0.05), and the infiltration of CD68-positive monocytes in the colon tissue of UC+Cit group was significantly reduced than that in UC group. The concentrations of MCP-1, IL-6 and IL-17A and the expression of p-STAT3 in colon tissues of UC+Cit group rats were significantly lower than those in UC group (both p less then 0.05). Our study suggests that Cit supplementation may be a potential therapy for UC. In vivo function