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The lowest FRE for vessel registration was reached with r=50mm (6.5±2.5mm), the highest with r=120mm (7.1±2.1mm). Clinical accuracy at the target lesion, resulted most accurate (TRE=8.8±5.0mm) in sub-volumes with a radius of 50mm. Smaller US sub-volumes resulted in lower average TREs when compared to larger US sub-volumes (Pearson's correlation coefficient R=0.91, p0.001). Our results indicate that there is a linear correlation between US volume size and registration accuracy at the tumor. Volumes with radii of 50mm around the targe