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7 ± 3.8% (n = 3) in rice, respectively. The results on quantitative analysis were similar to that of LC-MS and better than that obtained by using immunoaffinity column (IAC) or molecularly imprinted polymer (MIP). This protocol provided an efficient access to high-efficient online specific recognition of ZEN in cereals by using such an aptamer-affinity capillary monolithic column. V.In this work, the impact of biological matrices, such as plasma and urine, was evaluated under SFCHRMS in the field of metabolomics. For this purpose, a repr