https://www.selleckchem.com/pr....oducts/vorolanib.htm
R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops, we mapped RNADNA hybrids, markers of ****tion fork stalling and DNA double-strand breaks along the human genome. This analysis indicates that transient ****tion fork pausing occurs at the transcription termination sites of highly expressed genes enriched in R-loops and prevents head-on conflicts with transcription, in a topoisomerase I-dependent manner.We have recently identified the MYC proto-oncogene, bHLH transcription factor (
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