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These findings highlight the importance of tumor-infiltrating B cells as drivers of antitumor immunity and their potential role in the regulation of myeloid-derived suppressor cells.Understanding tipping point dynamics in harvested ecosystems is of crucial importance for sustainable resource management because ignoring their existence imperils social-ecological systems that depend on them. Fisheries collapses provide the best known examples for realizing tipping points with catastrophic ecological, economic and social consequences. How