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Among the selective TRPV4 antagonists identified, compound 6 was the most active with an IC50 of 5.3 μM. This study represents the first report of semisynthetic homodrimane TRPV4 antagonists, selective over TRPV1, and potentially useful as pharmacological tools for the development of novel TRPV4 channel modulators.Mitochondria are the first-line defense of the cell in the presence of stressing processes that can induce mitochondrial dysfunction. Under these conditions, the activation of two axes is accomplished, namely, (i) the mito

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Two patients presented with strangulated hernias requiring laparotomy and bowel resection. Median follow up time was 53 months (IQR 12-141) for the entire cohort. We had one recurrence (6.2%) in a patient with laparoscopic repair. Diaphragm hernia repair after sequential left ventricular assist device explantation and orthotopic heart transplant is feasible and appears to be safe. When diagnosed, patients should be referred for surgical evaluation. Diaphragm hernia repair after sequential left ventricular assist device explantation and