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g rates over time. These results may inform interventions focused on improving cancer control and prevention of other chronic conditions among cancer survivors. Epigenome-wide association studies using peripheral blood have identified specific sites of DNA methylation associated with risk of various cancers and may hold promise to identify novel biomarkers of risk; however, few studies have been performed for pancreatic cancer and none using a prospective study design. Using a nested case-control study design, incident pancreatic cancer