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Antiretroviral therapy (ART) has been proven effective in reducing the mortality rates among people living with HIV/AIDS (PLWH). However, poor adherence to ART may result in treatment failure. Few studies examine the relationship between spousal intimacy, type of ART and ART adherence. This study aimed to investigate the association between spousal intimacy, type of antiretroviral therapy (ART) and antiretroviral therapy adherence among PLWH in Bandung, Indonesia. A cross-sectional study was conducted involving 115 adult PLWH who were r