https://www.selleckchem.com/products/ag-825.html
We previously showed that lifelong rapamycin treatment of short-lived Apc mice, a model for familial adenomatous polyposis, resulted in a normal lifespan. Apc mice develop colon polyps with a low frequency but can be converted to a colon cancer model by dextran sodium sulfate (DSS) treatments (Apc -DSS model). We asked, what effect would pretreatment of Apc mice with chronic rapamycin prior to DSS exposure have on survival and colonic neoplasia? Forty-two ppm enteric formulation of rapamycin diet exacerbated the temporary weight loss ass
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