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A 35-fold decrease in the peak concentration (Cmax) of active (S)-carvedilol and a 19% decrease in the area under the curve (AUC) from time zero to infinity was observed in post-roux-en-Y gastric bypass patients, contrasted with non-obese participants. The time taken for (S)-carvedilol to achieve its maximum concentration was significantly prolonged (25 times) in post-Roux-en-Y gastric bypass patients, as compared to obese and nonobese individuals. In the absence of an asses
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