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Multiplex immunofluorescence shows that melanocytes may also weakly express PSMA. Conclusion Performance of PSMA immunohistochemistry in melanoma metastases rivals that reported in prostate cancer studies. This study indicates that PSMA shows promise for use as a novel biomarker in melanoma and justifies further research in the clinical setting with potential as a PET/CT radiotracer and intraoperative fluorescence marker for melanoma. This article is protected by copyright. All rights reserved.The present study is to isolate and characte