https://www.selleckchem.com/pr....oducts/luzindole.htm
Genetic or acquired defects in FOXP3 regulatory T cells (Tregs) play a key role in many immune-mediated diseases including immune dysregulation polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Previously, we demonstrated CD4 T cells from healthy donors and IPEX patients can be converted into functional Treg-like cells by lentiviral transfer of (CD4 ). These CD4 cells have potent regulatory function, suggesting their potential as an innovative therapeutic. Here, we present molecular and preclinical data supporting CD4 cell cl
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