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Detailed treatment planning and execution are crucial if regenerative approaches are to be attempted to retain fused permanent teeth. Long-term follow-up is necessary to monitor the stability of the final outcome, both esthetically and functionally.This case report underlines the importance of molecular characterization of genomic duplications and other structural variants in the prenatal setting to guide clinical interpretation, genetic counseling, and perinatal medical care.Dietary modifications in certain IEMs are highly cariogenic, s