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39, 95% CI = 0.22-4.57). Subgroup analysis based on ethnicity, a significant association for the high level of Cys C with the risk of MCI was observed in the Asian population (SMD = 1.63, 95% CI = 0.44-2.82) but not in the Caucasian population (SMD = 2.80, 95% CI = [-0.66]-6.26). Cys C was associated with MCI, and it could be considered as a predictor for the risk of cognitive impairment. Cys C was associated with MCI, and it could be considered as a predictor for the risk of cognitive impairment.Stroke is a debilitating disease a