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This study was carried out to evaluate the antiplasmodial activity of alcoholic and hydroalcoholic extract of stem bark as well as the determination of core structure fractionated from its crude extract. The antiplasmodial activity of stem bark extracts was investigated by schizont maturation inhibition assay against (both chloroquine sensitive and resistant). The crude extract was analyzed by gas chromatography-mass spectrophotometry (GC-MS). Both alcoholic and hydroalcoholic extracts showed their potential toward antiplasmodial activity against strains MR