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The objective of this retrospective study was to define the rate of central nervous system involvement among diffuse large B-cell lymphoma (DLBCL) patients, while simultaneously characterizing its predisposing factors and the consequent survival outcomes. Forty-six (42%) of the 406 diffuse large B-cell lymphoma (DLBCL) patients were found to have central nervous system (CNS) involvement. At initial diagnosis, 9 (22%) presented with CNS involvement; 8 (~2%) cases experienc