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In terms of performance for all outcomes, the PELOD-2 organ dysfunction score held the highest standing. This study aimed to investigate the serum YKL-40 alterations and their predictive value in acute ischemic stroke (AIS) patients diagnosed with diabetes mellitus (DM). In a study of 121 patients with DM and AIS, serum YKL-40 was assessed using ELISA at baseline and on days 1, 3, 7, and 30 subsequent to the initiation of the disease. YKL-40 levels demonstrably increased from the starting point to day 3, then decreased gradually