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20; 95%CI 1.29-3.75), patients who had opportunistic infection (AOR=1.98; 95%CI 1.27-3.11), poor medication adherence (AOR=1.79; 95%CI 1.13-2.85) and high HIV-related perceived stigma (AOR=1.66; 95%CI 1.04- 2.67) were more likely depressed compared to their counterparts. In this study, male ****, those patients living in urban areas, having opportunistic infections, poor medication adherence, and high HIV-related perceived stigma were significantly associated with depression. Hence, organizations working on HIV programs should address the