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Attempts to overcome this issue will be also revised. In particular we will discuss how the application of -omics integrated approaches could provide the determinants of response to the different targeted drugs.One interesting phenomenon of Chrysanthemum morifolium tea is its formation of a green or dark green color after hours of brewing, and it is important to study the compounds that form this color and whether they might be involved in health benefits. Non-targeted metabolomics could clearly distinguish between green and non-green spec