https://www.selleckchem.com/products/shr0302.html
The superfamily 1 helicase nonstructural protein 13 (nsp13) is required for SARS-CoV-2 ****tion. The mechanism and regulation of nsp13 has not been explored at the single-molecule level. Specifically, force-dependent unwinding experiments have yet to be performed for any coronavirus helicase. Here, using optical tweezers, we find that nsp13 unwinding frequency, processivity, and velocity increase substantially when a destabilizing force is applied to the RNA substrate. These results, along with bulk assays, depict nsp13 as an intrins
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