https://www.selleckchem.com/
In several metazoans, the number of active ****tion origins in embryonic nuclei is higher than in somatic ones, ensuring rapid genome duplication during synchronous embryonic cell divisions. High ****tion origin density can be restored by somatic nuclear reprogramming. However, mechanisms underlying high ****tion origin density formation coupled to rapid cell cycles are poorly understood. Here, using Xenopus laevis, we show that SSRP1 stimulates ****tion origin assembly on somatic chromatin by promoting eviction of histone H1 through its N-termi
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