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Importance "Not relevant" responses (NRRs) on the Dermatology Life Quality Index (DLQI) are common among patients with psoriasis and may be associated with an underestimation of disease severity. Objective To evaluate the associations between (1) patient sociodemographic characteristics and the frequency of NRRs on the DLQI and (2) NRR frequency and treatment satisfaction. Design, Setting, and Participants This cross-sectional study using data from the Dermatology Clinical Effectiveness Research Network from February 2010 to June 2011 as