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s. Patient populations and unit factors need to be carefully considered and procedures developed to manage unique challenges.BACKGROUND Hospital-Acquired Infections (HAIs) are acquired when the patient is hospitalized for more than 48 hours. In Ethiopia data are scarce in management appropriateness of HAIs. Hence, this study was aimed to assess the prevalence and management of HAIs among patients admitted at Zewditu Memorial Hospital. METHOD A facility based prospective cross sectional study was conducted from March 1, 2017 to August 30,