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Fifty percent of participants reported at least one ADR with a total of 239 unique ADRs. Fatigue (n=26) and headache (n=2 resulted in the highest burden and a correlation in time with the administration of the biological was described in 56% and 85% respectively. Out of 239 ADRs, 115 were considered biological-related. HCPs reported 119 ADRs. Agreement between patient-reported ADRs and HCP-reported ADRs was only 13%. IBD patients often report ADRs during biological therapy. We observed an important significant difference between the ty