https://www.selleckchem.com/pr....oducts/pyrrolidinedi
naling following CCH; therefore, reversal of BBB dysfunction may be a promising strategy for CSVD treatment. Our results indicate that reduced pericyte coverage leads to increased BBB permeability via endothelial transcytosis. Imatinib executes a protective role on the BBB integrity via inhibition of endothelial transcytosis. Maintenance of BBB integrity ameliorates brain damage through regulation of TGF-β/Smad2 signaling following CCH; therefore, reversal of BBB dysfunction may be a promising strateg
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