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Melatonin (MLT) levels fluctuate according to the external light/dark cycle in both diurnal and nocturnal mammals. We previously demonstrated that MT2 receptor knockout (MT2 -/- ) mice show a decreased non-rapid eye sleep over 24-hr and increased wakefulness during the inactive (light) phase. Here, we investigated the role of MT2 receptors in physiological light/dark cycle fluctuations in the activity of dorsal raphe nucleus (DRN) serotonin (5-HT) neurons and anxiety- and depression-like behaviour. We found that the 5-HT burst-firing ac
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