https://www.selleckchem.com/pr....oducts/atglistatin.h
Lung cysteine cathepsin S (CatS) that is a potent elastase plays a deleterious role in alveolar remodeling during smoke-induced emphysema. Despite the presence of a reactive nucleophilic cysteine (Cys25) within its active site, most of its elastinolytic activity is preserved after exposure to cigarette smoke extract (CSE), a major source of sulfhydryl oxidants. This result led us to decipher CatS resistance to major and representative CSE oxidants hydrogen peroxide, formaldehyde, acrolein and peroxynitrite. CatS was inactivated by h
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