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4D phase contrast magnetic resonance imaging (PC-MRI) allows for the visualization and quantification of the cerebral blood flow. A drawback of software that is used to quantify the cerebral blood flow is that it oftentimes assumes a static arterial luminal area over the cardiac cycle. Quantifying the lumen area pulsatility index (aPI), i.e. the change in lumen area due to an increase in distending pressure over the cardiac cycle, can provide insight in the stiffness of the arteries. Arterial stiffness has received increased attention as