https://signalingmolecule.com/....pure-erythroid-leuke
Mechanistically, our data reveal that the unregulated activity of the mitotic MUS81 enzyme in the S-phase causes the cleavage of stalled ****tion forks before they can be reversed, avoiding fork deprotection and activating a polymerase-dependent DNA double-strand break repair mechanism. Our findings collectively delineate a novel mechanism for PARPi resistance, which centers on MUS81-dependent cleavage of unbroken, unreversed ****tion forks. Our observation of th
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