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Data from the US suggest that chronic hepatitis B (CH patients have aged in the past decade. However, the burden of non-liver comorbidities have not been well characterized in Taiwan, where CHB is very prevalent. Our study examined this issue as it presented between 2001 and 2011in Taiwan. This study identified adult patients (≥18 years) who were diagnosed with CHB in 2001, 2006, and 2011, from the Taiwan National Health Insurance Research Database (NHIRD). Changes in demographic characteristics, prevalence of non-liver comorbidities,
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