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Results For BMSMO who had a high ****ual risk profile the syndemic factors characterizing this group included perceived racism, incarceration, IPV, depression, and binge drinking. For BMSMW with a high ****ual risk profile, the syndemic factors that characterized this group were incarceration, depression, and binge drinking. Conclusions The current analysis highlights syndemic profiles that differentiated BMSMO and BMSMW from one another and support the need for tailored interventions that address specific syndemic factors for both subpopu