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Notably, two patients had variants in more than one gene. The identification and validation of new pathogenic ABCA12, ALOX12B, CYP4F22, and SULT2B1 variants through multi-gene NGS in four cases of ARCI further highlight the importance of these genes in proper skin function and development.Real-world datasets are often contaminated with label noise; labeling is not a clear-cut process and reliable methods tend to be expensive or time-consuming. Depending on the learning technique used, such label noise is potentially harmful, requiring an i
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