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Effects of high protein (HP) diets and prolonged energy restriction (ER) on integrated muscle protein kinetics have not been determined. The objective of this study was to measure protein kinetics in response to prolonged ER and HP on muscle protein synthesis (MPS; absolute rates of synthesis) and muscle protein breakdown (MPB; half-lives) for proteins across the muscle proteome. Female 6-wk-old obese Zucker rats (Leprfa+/fa+, n=48) were randomly assigned to one of four diets for 10 wk ad libitum-standard protein (AL-SP; 15%kcal from pro
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