https://www.selleckchem.com/pr....oducts/msu-42011.htm
Administration of 20 mg/kg ZMEO could significantly increase chronic seizure threshold and latency while reducing frequency of convulsions and mortality in the PTZ-induced model. In studied doses, ZMEO could not protect mice from HLTE and mortality induced by MES. Pretreatment with L-arginine and diazepam potentiated anticonvulsant effects of ZMEO while pretreatment with L-NAME, Aminoguanidine and flumazenil reversed anticonvulsant activity. In conclusion, recorded anticonvulsant activity of ZMEO may be mediated in part through GABAer
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