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The first integrative documentation and evaluation of Rhodiola rosea extracts and salidroside's induction of hormetic effects is presented in this paper. These research findings have profound biomedical applications and are expected to impact significantly on study design, dose selection, and other experimental features. S1P, a bioactive lipid molecule, employs its receptor, S1PR, to regulate various cellular functions across differing cell types. Chronic pancreatitis (CP) exhibits a