https://www.selleckchem.com/pr....oducts/tocilizumab.h
Identifying attributes that distinguish pre-malignant from senescent cells provides opportunities for targeted disease eradication and revival of anti-tumour immunity. We modelled a telomere-driven crisis in four human fibroblast lines, sampling at multiple time points to delineate genomic rearrangements and transcriptome developments that characterize the transition from dynamic proliferation into ****tive crisis. Progression through crisis was associated with abundant intra-chromosomal telomere fusions with increasing asymmetry