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Each of the two investigators independently extracted the data and evaluated the risk of bias. With PROSPERO, CRD42022345419, the study protocol was recorded prospectively. After identifying a total of 32,543 studies, 44 were deemed appropriate for the study. Experimental in vitro procedures determined the consequences of flow adjustments on the percentage of inspired oxygen (FiO2). O Positive end-expiratory pressure (PEEP), along with carbon dioxi