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Laboratory experiments performed on mesenteric arterial endothelial cells (MAECs) illustrated that TFA decreased the TNF-induced elevation of ICAM-1, VCAM-1, MAdCAM-1 levels, and the adhesion of THP-1 cells to the MAECs. By acting on MAECs, TFA stopped the phosphorylation and nuclear entry of NF-κB. TFA's powerful effect on UC might be attributed to its ability to suppress monocyte adhesion. This action is achieved by inhibiting the T